The story was to be focused on Mallet Island, home to an Umbrella facility. Tony maintains a human form, but possesses superior skills and intellect. Spencer, Earl Spencer who have become superhumans through the use of the Progenitor Virus.
According to Hideki Kamiya and some sources, the story was based on unravelling the mystery surrounding the protagonist Tony Redgrave and his twin brother Paul Redgrave, the sons of Oswell E.